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Download Le Cancer du rein (Oncologie pratique) by Stephane Culine, Jean-Jacques Patard PDF

By Stephane Culine, Jean-Jacques Patard

Une meilleure connaissance de l’?pid?miologie, des caract?ristiques pathologiques, des cibles mol?culaires coupl?s ? des progr?s des moyens d’imagerie ont conduit ? des ?volutions consid?rables dans l. a. prise en cost des melanoma du rein. Les tumeurs localis?es sont d?couvertes ? un stade plus pr?coce. Le proposal de surveillance energetic ?merge. Des traitements mini-invasifs comme l. a. cryoth?rapie ou los angeles radiofr?quence pour des cas s?lectionn?s sont maintenant accessibles. Les symptoms de los angeles n?phrectomie partielle ouverte ?lective s’?largissent et l. a. n?phrectomie partielle laparoscopique puis robotique sont en cours d’?valuation. Longtemps confront?e aux limites de l’immunoth?rapie, l. a. prise en cost des stades m?tastatiques est en voie d’?tre profond?ment modifi?e par le d?veloppement des th?rapies cibl?es dirig?es contre les effecteurs de l’angiog?n?se tumorale, avec une am?lioration significative de los angeles survie. L’?re de los angeles prise en cost pluri-disciplinaire des cancers du rein a commenc?.

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Les mutations retrouvdes dans les familles atteintes et dans des carcinomes papillaires sporadiques activent le domaine tyrosine kinase de fagon constitutive (30). Une trisomie du chromosome 7 est tr~s frdquemment rencontrde dans les Ccllulc mlmlairc r~c Fig. 9- Principales voies moldculaires potentiellement ddrdguldes dans la carcinogdn~se rdnale. La perte de fonction de VHL, l'accumulation de fumarate secondaire 5. l'hypoxie relayde par HIF, participant 5. la pathogdnie des carcinomes 5. cellules claires et papillaires de type 2.

L'heure actuelle, parmi les enqu4tes de cohortes disponibles sur ce sujet, une seule semblerait confirmer cette association (47). R~f~rences 1. Tyczynski JE, Ddmaret E, Parkin DM (2003) Standards and guidelines for cancer registration in Europe, the ENCR recommendations, volume 1. IARC technical publication n~ IARC press, Lyon 2. World Health Organisation, Geneva (2000) International Classification of Diseases for Oncology, ICD-O, 3th edition 3. Remontet L, Est~ve Jet al. (2003) Cancer incidence and mortality in France over the period 1978-2000.

Ene et 5. des doses 4lev4es et la survenue de ces cas de cancer du rein (OR estim4 ~. 2,7) (44-46). Cependant, 5. l'heure actuelle, parmi les enqu4tes de cohortes disponibles sur ce sujet, une seule semblerait confirmer cette association (47). R~f~rences 1. Tyczynski JE, Ddmaret E, Parkin DM (2003) Standards and guidelines for cancer registration in Europe, the ENCR recommendations, volume 1. IARC technical publication n~ IARC press, Lyon 2. World Health Organisation, Geneva (2000) International Classification of Diseases for Oncology, ICD-O, 3th edition 3.

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