By Tapan K Basu, N Temple, Manohar L. Garg
Antioxidants play a big function within the development of significant human degenerative illnesses and stipulations. This booklet covers antioxidants and their mechanisms of motion; their function in an entire array of stipulations together with heart illness, malignant sickness, diabetes, cataracts, breathing affliction, cystic fibrosis, cognitive services, and getting older; their signs for oxidative tension; and patron concerns. the vast majority of chapters were constructed from papers awarded on the sixth global Congress in medical foodstuff, held in Banff, Canada, July 1997.
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Additional resources for Antioxidants in Human Health and Disease
1996). K. Basu detrimental to the cell through generating large quantities of free radicals. There are, however, two circulating iron-binding proteins: transferrin and ferritin which, to some extent, counteract the toxicity of moderately excessive quantities of iron in the body. In addition to endothelial cells, other arterial cells are also believed to be affected by oxidative processes, and the changes induced in these cells may contribute to the progression of atherosclerosis. , 1993). The likely candidate responsible for the oxidative modification of LDL and arterial cells, is the oxygen-derived free radical.
1975) Ascorbic acid in cholesterol and bile acid metabolism. Annals of the New York Academy of Science 258, 410–421. Gorog, P. (1992) Neutrophil-oxidized low density lipoprotein: generation in and clearance from the plasma. International Journal of Experimental Pathology 73, 485–490. M. (1994) Biological origin of free radicals, and mechanisms of antioxidant protection. Chemico-Biological Interactions 91, 133–140. 02 Antioxidants 24/5/99 11:05 am Page 25 Potential Role of Antioxidant Vitamins 25 Halliwell, B.
Being derived from protein, the levels of these antioxidants are determined by their rate of synthesis, and therefore cannot be manipulated easily. In addition to these endogenous antioxidants, one can obtain oxygen scavengers from dietary sources. The common dietary antioxidants are tocopherols (vitamin E), ascorbic acid (vitamin C), carotenoids and flavonoids. Since these dietary antioxidants are exogenous in nature, their levels can be manipulated by supplements and dietary modifications. There also appear to be a variety of synthetic compounds such as probucol and butylated hydroxytoluene (BHT), with an antioxidant activity.