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By Le Khang

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2000). Also, the cost per delivery of IUI is high in the 3rd and 4th cycles of IUI, because of the decreasing conception rates. There is preliminary evidence that complementing established treatment modalities by food supplementation may decrease the time to pregnancy, reducing the cost per delivery. The cost per delivery of IVF for male subfertility is highest, even more when used in older women (Legro et al. 1997), while ICSI may be slightly better from this point of view because of the higher immediate success rate.

Tim Hargreave has developed this brief summary from a longer guideline prepared by himself, Dr David Griffin, and Professor Ruth Maklin for the Reproductive Health Research Programme, World Health Organization, Geneva ■ ■ ■ Appendix Summary of Information About Research Samples that Should Be Given to Research Subjects ■ ■ How confidentiality and privacy of personal information will be protected Where samples and any clinical information will be kept Who will have access to the samples and the research results Whether the results of the research will be relayed back to the research subject How long samples will be kept The final disposition of the samples and information What the Sample is and how the Sample will be Obtained ■ ■ ■ ■ ■ Degree of invasiveness In case of invasive procedures, any additional risks Arrangements for treating complications that may arise during or after invasive procedure to collect specimens Consequences of any variation in normal histopathological examination caused by specimen collection In the case of vaginal examination or other intimate examination, how privacy will be protected What Consent Is Being Asked?

Genetics – Peripheral blood karyotype – DNA, identification of genetic mutations – Fluorescence in situ hybridization (FISH) using SRY (sex-determining region on the Y chromosome) -specific probes (useful in clarifying the results of the karyotype) Endocrine – 17-Hydroxyprogesterone, 11-deoxycortisol, 17hydroxypregnenolone, dehydroepiandrosterone (DHEA), electrolytes, renin, aldosterone, adrenocorticotrophic hormone (ACTH), urine steroids ■ – Testosterone (T), dihydrotestosterone (DHT) – Androstenedione – Luteinizing hormone (LH), follicle-stimulating hormone (FSH), AMH (anti-Müllerian hormone) – hCG test (human chorionic gonadotrophin) Imaging – Pelvic ultrasound – MRI – Cystourethroscopy Surgical – Exploratory laparoscopy – Biopsy of gonads The commonest cause of newborn intersex is CAH due to 21-hydroxylase deficiency characterized by a 46, XX karyotype, increased 17-hydroxyprogesterone levels and the presence of a uterus (Speizer 2001) (Fig.

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