By A. Pilotto, P. Malfertheiner, P.R. Holt, T. Fulop
With the dramatic raise of the getting older inhabitants, the learn and care of gastrointestinal issues within the aged became precedence issues for either clinicians and researchers. The geriatric method along with the epidemiology and pharmacokinetics of gear in addition to a entire multidimensional evaluation is very very important in dealing with older sufferers with gastrointestinal issues, considering that those sufferers tend to have a number of interacting difficulties that intervene with their day-by-day functionality and complicate their remedy. This e-book offers the result of contemporary experiences in geriatric gastroenterology and stories either uncomplicated and scientific elements of the sphere. an enormous part is dedicated to the shut exam of the structural and sensible results of getting older at the body structure of the gastrointestinal tract.
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Extra info for Aging and the Gastrointestinal Tract
Ulrich Klotz Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Auerbachstrasse 112, D–70376 Stuttgart (Germany) Tel. de Aging and Drug Disposition 39 Effect of Aging on the Gastrointestinal Tract Pilotto A, Malfertheiner P, Holt PR (eds): Aging and the Gastrointestinal Tract. Interdiscipl Top Gerontol. N. , USA Esophagus: Disorders of Swallowing Oropharyngeal The normal swallowing mechanism is a complex coordinated interaction of neurologic, muscular and visceral components resulting in an orderly progression of a solid or liquid bolus from the mouth to the stomach.
Drugs 1988;36:132–157. Slikkerveer A, de Wolff FA: Pharmacokinetics and toxicity of bismuth compounds. Med Toxicol Adverse Drug Exp 1989;4:303–323. Treiber G, Gladziwa U, Ittel TH, Walker S, Schweinsberg F, Klotz U: Tripotassium dicitrato bismuthate: Absorption and urinary excretion of bismuth in patients with normal and impaired renal function. Aliment Pharmacol Ther 1991;5:491–502. Agrawal NM, Roth S, Graham DY, White RH, Germain B, Brown JA, Stromatt SC: Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer.
Age-related changes in physiology and drug disposition Klotz 36 might complicate the clinical problem. g. type and characteristics of elimination, enzymes involved in drug metabolism, actual GFR) should be known and applied. Most drugs have to be metabolized before final excretion and this hepatic elimination seems to be quite normal in advanced age, at least in the fit elderly. Likewise, the age-dependent decline in kidney function (GFR) is less marked and well preserved in the healthy elderly.