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By Abramenko P., Van Maldeghem H.

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The modular architecture of tumor-associated cell systems is directly embedded in the holistic totality of the tumor’s living world. 2). The advantage of a modular view of therapeutic interventions is the situative reference in topologies of aggregated action effects. The therapeutic value of the topologies of aggregated action effects lies in the presentation character of current communicative circumstances. Evolutionary reconstruction of tumor-associated systems. Redeeming validity is tailored on the relation of modular communication to the objective features of the tumor compartment, the reconstructible evolutionary (modular) systems, for example, indicated by differential impact of pro-inflammatory processes within the tumor system [6].

This demonstrates that tumor-promoting pro-inflammatory processes are differentially accessible from a communication-technical point of view and differentially constituted in their modularity. Nevertheless, CRP may serve as a unique modularlylinked systems marker to early show the efficacy of these therapies [6]. Most cells within the tumor compartment are constrained to respond to administered modular therapies: targeted molecules are ubiquitously available and partially constitutionally expressed, particularly certain receptors targeted with their respective stimulatory ligands, such as the glucocorticoid receptor, and peroxisome proliferator-activated receptor alpha/gamma.

I would like to thank M Schoell for the critical review of the article, and all the colleagues contributing in the multi-center trials. References 1. Nunn AV, Bell J, Barter P (2007) The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balance. Nucl Recept 5: 1. 2. Baker SG, Kramer BS (2007) Paradoxes in carcinogenesis: new opportunities for research directions. BMC Cancer 7: 151. 26 A. Reichle 3. Folkman J, Kalluri R (2004) Cancer without disease.

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